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Calcium Bilirubinate Gallstone Treatment

Calcium bilirubinate gallstones are a type of gallbladder stone. At Pristyn Care, we are committed to providing the best surgical treatment for gallstones. We utilize the latest and most advanced surgical techniques, including laparoscopic cholecystectomy for gallstones removal. Book a consultation with our laparoscopic surgeons today and undergo effective surgery for calcium bilirubinate gallstones.

Calcium bilirubinate gallstones are a type of gallbladder stone. At Pristyn Care, we ... Read More

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What is a Calcium Bilirubinate Gallstone?

Gallstones are hard, pebble-like pieces of material, usually made of cholesterol or bilirubin, that form in the gallbladder. Gallstones can vary in size from a grain of sand to a golf ball. The gallbladder can make one large gallstone, hundreds of tiny stones, or both small and large stones.

There are two main types of gallstones: cholesterol gallstones and calcium bilirubinate gallstones. A calcium bilirubinate gallstone, also called a pigment stone, is a kind of gallstone that is composed mainly of bilirubin, a yellow pigment that is made when red blood cells are broken down. Bilirubin is usually processed by the liver and excreted in bile, which assists digestion. However, under certain situations, excessive bilirubin can collect in the bile and form gallstones.

Calcium bilirubinate gallstones generally have a dark brown or black color and are softer and more brittle than other gallstones. They are often linked with certain medical conditions, such as liver cirrhosis (a condition in which the liver is scarred and permanently damaged), chronic hemolytic anemia (a condition where red blood cells are destroyed faster than they are made), and inherited disorders like sickle cell disease. The formation of calcium bilirubinate gallstones is due to numerous factors, including increased bilirubin production, reduced bile flow, and alterations in the composition of bile. 

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Diagnosis And Treatment of Calcium Bilirubinate Gallstone

Diagnosis

If your healthcare provider thinks you might have gallstones, you will likely have further testing—most likely imaging, like an ultrasound or computerized tomography (CT) scan. Here are some tests and procedures commonly used to diagnose calcium bilirubinate gallstones:

  • Ultrasound: Ultrasound utilizes sound waves to see the bile ducts, liver, and pancreas. When calcium bilirubinate gallstones are present, they are noticed either in the gallbladder or bile ducts. Ultrasound is the first test that is considered if a healthcare provider suspects gallstones.
  • Endoscopic Ultrasound: Endoscopic ultrasound uses a scope that has an ultrasound on the end of the instrument. This ultrasound scope is passed down into the intestines, where healthcare professionals can get an internal visualization of the bile ducts, gallbladder, and pancreas ducts. Special training is needed to use endoscopic ultrasound, which is sometimes used to find bile duct stones that may be missed by regular ultrasound. 
  • Computerized Tomography (CT) Scan: A CT scan can also be used to detect and assess calcium bilirubinate gallstones. While ultrasound is often the preferred and most effective way to diagnose gallstones, a CT scan can provide more information in some instances. A CT scan can develop detailed cross-sectional images of the abdomen, including the gallbladder and bile ducts. It can notice the presence of calcium bilirubinate gallstones and provide information about their size, number, and location.
  • Endoscopic Retrograde Cholangiopancreatography (ERCP): ERCP is another kind of endoscope test performed with X-rays that allows access to the gallbladder and bile ducts. The ERCP test also enables gallstones discovered during the procedure to be removed from the bile or pancreatic ducts. This test is fairly invasive.
  • Magnetic Resonance Cholangiopancreatography (MRCP): Magnetic Resonance Cholangiopancreatography (MRCP) is a non-invasive imaging technique that utilizes magnetic resonance imaging (MRI) to visualize the bile ducts, gallbladder, and pancreatic ducts. MRCP helps evaluate the biliary system and can provide clear images of the bile ducts without requiring invasive procedures. This test can help differentiate between different kinds of gallstones, including calcium bilirubinate stones. The distinctive appearance of these stones can be observed on MRCP images, which helps in their identification.
  • Hydroxyl Iminodiacetic Acid (HIDA) Scan: A Hydroxyl Iminodiacetic Acid (HIDA) scan, also known as hepatobiliary scintigraphy, is an imaging test used to assess the function of the gallbladder, liver, and bile ducts. The test involves injecting a radioactive tracer called hydroxyl iminodiacetic acid into the bloodstream, which is taken up by the liver and passed into the bile. This scan can assess the emptying and contraction of the gallbladder and track bile flow from the liver into the bile ducts and ultimately into the small intestine. It can detect any abnormalities or blockages in the bile ducts, including strictures, tumors, or gallstones, including calcium bilirubinate stones.
  • Complete blood count (CBC): A CBC estimates the levels of different blood cells, including red blood cells, white blood cells, and platelets. Certain conditions associated with calcium bilirubinate stones formation, such as chronic hemolytic anemia or inflammation, may cause specific changes in the CBC.
  • Liver function tests (LFTs): LFTs measure levels of several enzymes, proteins, and bilirubin in the blood, providing an overall assessment of liver health and function. Abnormalities in LFTs can indicate liver disease or dysfunction that may contribute to calcium bilirubinate gallstone formation.

Treatment

Typically, calcium bilirubinate gallstones are treated only if they cause symptoms. For recurrent gallstone symptoms like sudden and rapidly intensifying pain in the upper right portion of your abdomen and back pain between your shoulder blades, the most effective treatment is the surgical removal of the gallbladder or cholecystectomy. There are 2 main ways of removing a gallbladder:

  1. Laparoscopic (keyhole) cholecystectomy- Laparoscopic cholecystectomy is a minimally invasive surgical procedure performed to remove the gallbladder. It is performed using 4 to 5 small incisions in the abdomen. A laparoscope, a long, thin tube with a camera attached to it, is inserted through one of the incisions. The laparoscope helps the surgeon to see the gallbladder and surrounding structures on a video monitor. Specialized surgical instruments are then inserted through the other incisions to remove the gallbladder.
  2. Open cholecystectomy- Open cholecystectomy is a surgery to remove the gallbladder through a large cut in your abdomen. During an open cholecystectomy, the surgeon makes a 6-inch (15-centimeter) incision in the abdomen below the ribs on the right side. The muscle and tissue are pulled back to expose the liver and gallbladder. The gallbladder is then gently lifted out and removed from the body. Your vital signs, pain levels, intake and output, and incision site will continue to be monitored until you are released home.

Are you going through any of these symptoms?

Which Is The Most Effective Surgical Treatment Option For Calcium Bilirubinate Gallstones?

The most effective surgical treatment option for calcium bilirubinate gallstones is laparoscopic cholecystectomy. The decision to perform laparoscopic cholecystectomy is generally based on the symptoms, the size and number of stones, associated complications, and the patient’s general health status. It is considered the most effective treatment option for calcium bilirubinate gallstones due to several reasons:

  1. Lower Complication Rates: Laparoscopic cholecystectomy results in lower rates of complications compared to open surgery. The risk of infection, bleeding, and other surgical complications is generally minimized with the laparoscopic approach, leading to a safer and more effective treatment option.
  2. Faster Recovery: Laparoscopic cholecystectomy results in a quicker recovery than open surgery. Patients normally experience less pain and discomfort, have shorter hospital stays, and can return to everyday activities sooner.
  3. High Success Rate: Laparoscopic cholecystectomy has a high success rate in removing calcium bilirubinate stones. 
  4. Lowered Risk of Common Bile Duct Injury: Compared to open surgery, laparoscopic cholecystectomy has a lower risk of damaging the common bile duct. Laparoscopic surgery allows for clear visualization of the surrounding structures, minimizing the chances of accidental damage to the bile duct during the procedure.
  5. Minimal Scarring: An open gallbladder surgery will leave a big scar on the abdomen. However, a laparoscopic gallbladder surgery leaves only four to five tiny, unnoticeable scars. The largest of the scars is only about an inch long, and the others are even smaller.
  6. Less Postoperative Pain and Discomfort: Laparoscopic cholecystectomy typically results in less postoperative pain and discomfort. The smaller incisions and reduced tissue trauma lead to a more comfortable and smooth recovery process.
  7. Lower Risk of Wound Complications: The smaller incisions used in laparoscopic cholecystectomy leads to fewer wound complications, such as infection and hernia formation. This benefits patients, as it reduces the likelihood of further medical interventions and facilitates faster healing.

How To Prepare For A Cholecystectomy?

Here are some general tips to help you prepare for a cholecystectomy:

  1. Tell your surgeon about any medications or supplements you take. They will provide instructions on whether to continue or temporarily discontinue any specific medications or supplements before your surgery. It is essential to follow these instructions to reduce potential complications.
  2. Tell your doctor if you are pregnant or think you could be pregnant.
  3. Follow the fasting instructions provided by your surgeon. Generally, you will be instructed not to eat or drink anything, including water, for a certain duration before the surgery. This is required to empty the stomach and lower the risk of complications during anesthesia.
  4. Take a shower the night before your surgery or the same morning. Your surgeon might ask you to use an antibiotic soap. Also, do not shave your belly area.
  5. Since you will be obtaining anesthesia, it is vital to arrange for someone who can drive you to and from the hospital on the day of the surgery. You may also need someone to stay with you for the first 24 hours after your surgery.
  6. Bring your insurance cards, a form of ID, and a list of all current medicines on the day of your surgery.
  7. Depending on the nature of your job and the type of surgery, you may need to take some time off work for recovery. Therefore, discuss with your surgeon to get an estimate of how much time you may require and plan accordingly.
  8. Wear loose-fitting and comfortable clothes, and keep any valuables or jewellery at home on the day of your surgery.
  9. Sufficient rest is essential before undergoing surgery. Ensure you get sufficient sleep in the days leading up to the procedure. This will help your body prepare for the surgery and enable a smoother recovery.
  10. If you are a smoker, it is advisable to quit smoking before the surgery. Smoking can increase the risk of complications and slow down the healing process. Quitting smoking will have multiple benefits for your overall health and surgical outcomes.

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What Are The Postoperative Care Tips To Follow After A Cholecystectomy For Calcium Bilirubinate Gallstones?

 Here are some general postoperative care tips to follow after a cholecystectomy:

  • For a better recovery after surgery, the patient needs to avoid constipation. To do so, it is recommended to consume high-fiber foods, such as fruits and vegetables, to make stool bulkier and softer. It is also important to stay hydrated by drinking enough water, around 8-10 glasses/ day, and refrain from straining during bowel movements.
  • A day after surgery, the patient is advised to start eating a clear fluid diet and soup. During the first week after surgery, easy-to-digest food should be consumed. Hereafter, a regular diet can be slowly resumed while watching for bloating and abdominal discomfort.
  • Rather than having 3 big meals a day, it is better to split into 4-6 mini-meals each day to enhance proper digestion. A late meal at night that likely causes bloating and stomach discomfort must be avoided. Also, excess consumption of greasy food or cooked with extra oils, cheese, and other food containing trans fat must be avoided. The average amount of dietary fat the patient should consume should not exceed 30% of the recommended daily amount (60 grams of total fat).
  • To continuously encourage mobilization and prevent blood clot formation, especially in the legs, the patient should slowly resume daily tasks and activities, starting from getting up and walking. Lifting heavy objects (heavier than 6 to 7 kg) and strenuous exercise are not recommended for at least 4 to 6 weeks after surgery. 
  • Keep the surgical wound (incision) clean and follow the surgeon’s instructions on how and when to replace the bandage.  
  • It is very common to experience some minor bleeding from the incision. However, immediate medical assistance must be sought if it bleeds too much and the incision becomes moist. 
  • Avoid wearing tight or coarse clothes to prevent wound irritation that largely interrupts the wound-healing process. 
  • Assisted breathing devices (an incentive spirometer) should be continuously used for 3 to 5 days, as advised by your surgeon. To restore lung function and prevent lung infections, deep breathing, 5 to 6 times each hour, is essential. 
  • Getting out of bed too quickly after surgery might lead to poor blood supply to the brain, causing sudden dizziness and falls. To get out of bed, roll onto your side, bend the knees until the legs hang over the side of the bed, then use the arms to lift the upper body and push off with the arms to stand up. 
  • It is important to maintain adequate sleep, up to 8 to 10 hours/day, to enhance the healing process and recovery. Poor sleep habits, like having an irregular sleep schedule or having too much caffeine or alcohol, can interfere with sleep quality. 
  • Be aware of any signs of complications such as excessive pain, fever, worsening incision redness or drainage, persistent nausea or vomiting, or jaundice (yellowing of the skin or eyes). If you experience any concerning symptoms, contact your healthcare provider instantly.
  • Attend all scheduled follow-up appointments with your healthcare provider. These appointments allow your surgeon to monitor your progress, address concerns, and ensure proper healing.

What Happens If Calcium Bilirubinate Gallstones Are Left Untreated?

Here are some possible complications that can arise if calcium bilirubinate gallstones are left untreated:

  • Intestinal Obstruction: Untreated gallbladder inflammation caused by calcium bilirubinate gallstones may cause an abnormal joining between the gallbladder and the intestines, called a fistula. This opening allows gallstones to pass into the intestine, which may result in a dangerous intestinal blockage that could result in dehydration, infection, or even death.
  • Biliary Colic: Gallstones, including calcium bilirubinate stones, can lead to biliary colic, which is characterized by intense pain in the upper abdomen or right upper quadrant. This occurs when a stone obstructs the bile duct, accumulating bile and triggering painful spasms. 
  • Peritonitis: Peritonitis is a severe infection that happens when bacteria infect the abdominal cavity. Chronic inflammation of the gallbladder caused by gallstones may result in a perforation (hole) in the gallbladder. This rupture increases the chance of peritonitis. Peritonitis may need surgical intervention, and if left untreated, this infection can be life-threatening.
  • Choledocholithiasis: If a gallstone passes from the gallbladder and gets lodged in the common bile duct, it can lead to choledocholithiasis. This condition blocks bile flow from the liver and gallbladder to the small intestine, potentially causing symptoms like jaundice, dark urine, clay-colored stools, abdominal pain, and pancreatitis (inflammation of the pancreas). Choledocholithiasis often requires surgery to clear the stone and restore bile flow.
  • Gallbladder Empyema or Gangrene: In extreme cases of acute cholecystitis, where the inflammation persists and the blood supply to the gallbladder is restricted, complications such as gallbladder empyema (pus-filled gallbladder) or gangrene (tissue death) can occur. These serious conditions may require emergency surgery and can be life-threatening if left untreated.
  • Increased Risk of Gallbladder Cancer: Although rare, long-standing calcium bilirubinate gallstones can increase the risk of developing gallbladder cancer. 75% of those with gallbladder cancer have gallstones too. Chronic inflammation and irritation of the gallbladder tissues caused by the presence of gallstones may lead to the formation of cancerous cells over time.

What Are The Possible Complications Of Cholecystectomy?

Cholecystectomy is generally considered a safe procedure. However, like any surgery, there are certain complications that can occur. Here are some possible complications:

  1. Bleeding: In rare cases, excessive bleeding can happen during or after cholecystectomy. 
  2. Infection: Infection at the surgical site or within the abdominal cavity is possible after surgery. Antibiotics are generally administered before and after surgery to reduce the risk of infection.
  3. Bile Duct Injury: During the surgery, there is a certain risk of injury to the bile ducts, which carry bile from the liver to the small intestine. Bile duct injuries can range from minor leaks to more extreme damage requiring additional surgical repair.
  4. Adverse Reaction to Anesthesia: Some individuals may experience complications related to anesthesia, such as an allergic reaction, respiratory concerns, or cardiovascular issues. These risks are typically low but can happen.
  5. Blood Clots: Cholecystectomy increases the risk of developing blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism). 
  6. Shoulder or Abdominal Pain: After surgery, some people may experience temporary shoulder pain due to the gas utilized to inflate the abdomen during the surgery. Abdominal pain and bloating are also common during the initial recovery period.
  7. Incision Complications: Incisions during surgery can sometimes result in complications such as inadequate wound healing, infection, or scarring. Proper wound care and following post-operative instructions can help minimize these risks.

It is essential to discuss the potential complications of cholecystectomy with your healthcare provider. They can help you weigh the risks against the benefits of the procedure.

Frequently Asked Questions

Is cholecystectomy a common procedure?

Yes, cholecystectomy is one of the most common surgical procedures. It is considered a safe and effective treatment for different gallbladder stones, including calcium bilirubinate gallstones.

How long does it take to recover from cholecystectomy?

Recovery time from Cholecystectomy can vary, but most people can resume normal activities within a week or two after laparoscopic cholecystectomy. However, it may take longer for those who undergo open surgery. 

Are there any dietary changes required after cholecystectomy?

After cholecystectomy, some people may experience problems digesting fatty foods. Gradually reintroducing a regular diet and monitoring the tolerance for certain foods can help determine any dietary adjustments required. In general, a well-balanced and healthy diet is advised.

Can calcium bilirubinate gallstones come back after cholecystectomy?

Once the gallbladder is removed, the risk of developing new calcium bilirubinate gallstones is eliminated. However, in rare cases, stones can develop in the bile ducts if there are residual stones or other underlying conditions. 

How long does the calcium bilirubinate gallstone removal surgery typically take?

The duration of cholecystectomy surgery can differ depending on factors such as the surgical approach (laparoscopic or open) and any additional procedures required. In general, a laparoscopic cholecystectomy can take 1 to 2 hours, while an open cholecystectomy may take longer. 

Can I drive after a cholecystectomy?

It is essential to avoid driving for a few days after cholecystectomy, particularly if you are taking pain medications that may impair your judgment or reflexes. Therefore, follow your surgeon’s guidance, wait until you are no longer experiencing pain, and feel comfortable before resuming driving.

Are there any long-term effects of gallbladder removal?

In most cases, gallbladder removal has no major long-term effects on overall health or digestive function. Most people can lead an everyday and healthy life without a gallbladder. However, some people may experience changes in bowel habits or digestion, such as increased frequency of bowel movements or intolerance to high-fat meals.

Can cholecystectomy cause weight gain?

Cholecystectomy itself does not cause weight gain. However, some people may experience weight changes due to dietary adjustments or changes in digestion. If you see significant and unexplained weight changes after your surgery, it is better to consult with your healthcare provider.

What is the cost of calcium bilirubinate gallstone removal surgery in India?

The cost of calcium bilirubinate gallstone removal surgery in India may range from Rs. 90,000 to Rs. 2,60,000. However, the cost of the surgery depends on several factors, such as the surgeon’s fees, anesthesia charges, length of hospital stay, pre-existing medical conditions, insurance coverage, etc.

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Medically Reviewed By
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Dr. Milind Joshi
26 Years Experience Overall
Last Updated : April 11, 2025

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