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Intravitreal Injections - Eye Injections For Diabetic Retinopathy Treatment

Intravitreal injections are the first line of treatment for diabetic retinopathy. Proper management of the condition is essential to preserve the vision. If you have been diagnosed with diabetic retinopathy, you should consult expert ophthalmologists to get proper treatment. Book a free consultation with Pristyn Care’s eye specialists and discuss your treatment options in detail.

Intravitreal injections are the first line of treatment for diabetic retinopathy. Proper management ... Read More

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  • What is an Intravitreal Injection?

    An intravitreal injection is a procedure of administering medications into the retina through the vitreous cavity. A syringe is used to inject the drug or medication inside the eye. These injections are administered for the treatment of retinal conditions, such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, etc. 

    The medicine used in these injections can be an anti-VEGF (vascular endothelial growth factor) drug or steroids, whichever is effective for the treatment of diabetic retinopathy. This method is chosen for the treatment of mild to moderate non-proliferative diabetic retinopathy treatment. 

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    Best Eye Clinic for Intravitreal Injections

    Pristyn Care is a dedicated healthcare provider where every patient can get comprehensive treatment for diabetic retinopathy and other eye-related conditions. We have multiple eye clinics across various cities to make proper treatment easily accessible for everyone. 

    At each eye center, we have a highly experienced team of ophthalmologists who are well-trained and have ample expertise in administering anti-VEGF and steroid injections. Under the care of our eye specialists, you will get optimal treatment. You can give us a call and book your free consultation with an eye specialist.

    How are the injections administered?

    Administering intravitreal injections is a clinical procedure. They can be given to the patient by placing them on a reclined chair. The steps involved are explained below- 

    • The eye and eyelids are numbed at first using drops or gel so that the injection doesn’t hurt. The numbing medicine can also be given through an injection. 
    • Then both eyes and eyelids are cleaned using Povidone-Iodine, which kills bacteria that lives around the eye. 
    • An eyelid speculum is used to keep the eyelids open during the procedure. 
    • Once the eye is prepped for the injection, the doctor will ask you to look in a specific direction. The location at which the medicine is injected will vary depending on the problem. 
    • The injection needle passes through the pars plana (the white part of the eye), and the medicine is injected into the retina. 
    • You might feel slight pressure with mild to no pain during the injection. The eye is again cleaned, and the speculum is removed. 

    This entire procedure takes about 10-15 minutes per eye. 

    What to expect after the injection?

    Usually, there will be no side-effect after administration of the injection. There will be no restrictions after taking the intravitreal injection. The only thing you have to do is to avoid potential contamination of the eye after the procedure. 

    For some time, you might feel like something is stuck in your eye, which is normal. But make sure that you don’t rub them. The eye specialist will give you the timeline for the next injection and also prescribe artificial tears to prevent dryness and surface irritation. 

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    Risks & Complications

    In some cases, the patient may develop the following complications- 

    • Eye pain or discomfort 
    • Floaters in the eye 
    • Increased sensitivity to light 
    • Decreased vision 
    • Inflammation in the eye 
    • Scratches on the cornea 

    Types of Intravitreal Injections

    Anti-Vascular Endothelial Growth Factor (anti-VEGF) 

    This medicine/drug halt the growth of the protein- vascular endothelial growth factor (VEGF), which causes overgrowth of the blood vessels in the retina. The overproduction of VEGF increases the permeability of the existing blood vessels, which causes them to leak. At the same time, the protein also results in the growth of new blood vessels that also bleed and leak fluid due to lack of oxygen. 

    The anti-VEGF medicine prevents the production of the protein that causes abnormal blood vessel growth. Therefore, it slows down the progression of diabetic retinopathy. The two most widely used anti-VEGF drugs are Lucentis (ranibizumab) and Avastin (bevacizumab). Both are monoclonal antibodies that bind various forms of VEGF and help to keep the condition in control.  

    Steroids 

    Three synthetic corticosteroids, i.e., triamcinolone acetonide, dexamethasone phosphate, and fluocinolone acetonide, are used to address diabetic retinopathy and other diabetes-related eye disorders. The steroid helps to stabilize and reconstitute the BRB, which constricts the capillaries and downregulates the angiogenic and inflammatory angiogenic cytokine expression. This preserves the visual function for the long term. 

    The steroids are known to be effective to some extent, but at the same time, they increase eye pressure which increases the risk of developing glaucoma. 

    Post-Injection Care Tips

    • Visit your eye doctor right away in case you experience severe pain, redness, vision loss, or discharge from the eye after the injections. 
    • Avoid rubbing your eyes entirely post-injection.  
    • Do not drive or operate heavy machinery until the anesthesia effects and wears off. 
    • Use the prescribed eye drops as directed by the doctor without fail. 
    • Avoid swimming or getting into water bodies for at least 3 days post-injection. 

    Alternative to Intravitreal Injections

    Laser Treatment 

    This treatment method involves using a laser to stabilize the new blood vessels that are weak and leaking. The heat from the laser creates small burns on the abnormal blood vessels and seals them properly. This helps to reduce the swelling in the retina by shrinking the blood vessels and preventing them from growing further. Multiple sessions of laser treatment are required to effectively inhibit blood vessel growth. 

    Vitrectomy 

    Surgical treatment is usually recommended to the patient in case of proliferative diabetic retinopathy in which a large amount of blood has collected in the gel, and there are extensive scar tissues. It involves the removal of some or all of the vitreous humor from the eye and replacing it with silicone oil or saline solution. A gas bubble may also be inserted to reattach the retina. 

    What happens if diabetic retinopathy is left untreated?

    If diabetic retinopathy is not controlled or treated on time, the damage to the retinal blood vessels can be severe. Due to diabetes, the condition will continue progressing, and the blood and fluid from the abnormal blood vessels will leak into the vitreous humor. This damages the retina and also increases the risk of developing macular edema. 

    The condition can ultimately lead to permanent vision loss. Therefore, seeking treatment as soon as possible is crucial. 

    FAQ

    Do intravitreal injections hurt?

    No, the eyes are numbed before injecting the medicine. Thus, you won’t feel any kind of pain or discomfort while the injection is being administered. 

    How many injections will I need to prevent the progression of diabetic retinopathy?

    The number of injections that will be required to slow down the progression of diabetic retinopathy usually depends on your response to the first injection. If the intravitreal injections are effective, they will be given at regular intervals. If not, then alternative treatment methods will be considered. 

    Will I regain the lost vision with the help of intravitreal injections?

    No, the injections are helpful in preventing further damage to the eye but cannot help to regain lost vision. The damage done to the blood vessels is irreversible. Thus, you might ask the doctor to determine the best method to regain vision. 

    Who should not be treated with anti-VEGF injections?

    A person with diabetic retinopathy can’t be given anti-VEGF injections in the following scenarios- 

    • In case you are allergic to the constituents of the anti-VEGF injections. 
    • If an injection is present in the eye or any other part of the body. 
    • If you are pregnant, breastfeeding, or trying to get pregnant. 
    • In case the patient has had a heart attack or stroke in the last 6 months. 
    • If the patient has uncontrolled high blood pressure or angina. 

    What happens if the intravitreal injections stop working?

    If the intravitreal injections stop working, the eye specialist will recommend using either laser surgery or vitrectomy, depending on the severity of the condition.  

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    Content Reviewed By
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    Dr. Pulgurti Ramgopal
    34 Years Experience Overall
    Last Updated : May 23, 2024